LanternTennesseeKnoxvilleWellness & HealthIV Therapy & Wellness Clinics

    Best IV Therapy & Wellness Clinics in Knoxville, Tennessee

    Areas served: Knoxville, TN and surrounding Knox County

    31 local businessesRanked by Lantern Score — a measure of reputation and business quality. We don't accept payment for placement.
    Updated April 15, 2026

    Knoxville's IV therapy and wellness clinic landscape has expanded significantly in recent years, with facilities concentrated in West Knoxville, downtown, and along Kingston Pike. This directory provides verified information on local providers offering hydration therapy, vitamin infusions, and wellness treatments. Clinics in the Knoxville area vary considerably in their medical oversight, treatment protocols, facility credentials, and service specializations.

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    86
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, Tennessee and surrounding areas
    ★★★★★5.0(491 Google reviews)

    The Wellness Room is Knoxville's premier aesthetic and wellness center owned and operated by Stephanie Snowden-Harman, a board-certified Nurse Practitioner with over 10 years of clinical experience and training from renowned plastic surgeons in Beverly Hills. They offer a comprehensive range of FDA-approved cosmetic treatments including Botox, dermal fillers, Ellacor skin tightening, microneedling, laser treatments, PRP therapy, IV vitamin therapy, and specialized services like cellulite reduction, hair restoration, and lash/brow enhancement. Stephanie's personalized approach and expertise in both aesthetic injectables and medical wellness procedures make them the trusted choice for natural-looking results without excessive downtime.

    Ideal clients: Clients seeking natural-looking aesthetic results, professionals wanting subtle enhancements, individuals interested in non-surgical skin rejuvenation, wellness-focused patients
    What sets them apart
    • Owner Stephanie Snowden-Harman is a board-certified Nurse Practitioner with extensive training from Beverly Hills plastic surgeons and specialization in hormone replacement therapy and cosmetic procedures.
    • Beyond injectables, they offer IV vitamin therapy, PRP treatments, laser skin treatments, microneedling, and body treatments like cellulite reduction and hair restoration.
    • Stephanie takes time to individualize care for each client, with particular expertise in treating diverse patient needs including specialized approaches for male clients.
    Cosmetic InjectablesIV TherapySkin TreatmentsAesthetic WellnessMedical-Grade
    Phone(865) 274-0199
    The Wellness Room
    Updated 4/15/26Learn More →
    86
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    Knoxville, TN
    Serves Farragut, Knoxville, TN and surrounding areas
    ★★★★★5.0(337 Google reviews)

    Prime IV Hydration & Wellness in Farragut offers customized IV therapy treatments designed to help clients look better, feel better, and perform better. Their services include rehydration, athletic performance support, anti-aging, hangover recovery, immunity boosting, and specialized treatments for jet lag, altitude sickness, and sun exposure. The clinic also provides injection therapies, beauty boosts with glutathione, liver detox, and massage chair relaxation during treatments. With flexible membership plans, same-day availability, and medical-grade oxygen therapy, Prime IV delivers 100% nutrient absorption directly into the bloodstream for optimal results.

    Best for: Convenient at-home hydrationAthletic performance optimizationLuxury wellness experience
    Ideal clients: Athletes and fitness enthusiasts, anti-aging and beauty-focused individuals, frequent travelers, busy professionals seeking wellness optimization
    What sets them apart
    • IV therapy bypasses the digestive tract entirely, delivering nutrients directly into the bloodstream with full absorption—compared to only 20% absorption from oral supplements.
    • Each client receives a personalized consultation to design a program based on their specific health objectives and lifestyle, with ongoing adjustments to ensure optimal results.
    • Treatments are administered in state-of-the-art massage chairs with heated head-to-toe features including percussion, kneading, and vibration for a relaxing wellness experience.
    IV TherapyWellnessHydrationAnti-AgingAthletic Recovery
    Phone(865) 328-9150
    Prime IV Hydration & Wellness - Farragut
    Updated 4/15/26Learn More →
    85
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, Tennessee
    ★★★★★5.0(213 Google reviews)

    Medispa At Choto is a full-service medical spa in Knoxville offering IV infusion therapy, weight loss coaching with metabolic testing, cosmetic injectables (Botox and fillers), laser treatments, facials, and skincare services. The practice blends medical science with spa treatments to help clients achieve healthy, youthful skin and bodies through scientifically proven products and procedures. They provide personalized consultations and customized treatment plans for anti-aging, beauty enhancement, and wellness goals.

    Best for: Advanced longevity therapyLuxury wellness experience
    Ideal clients: Anti-aging clients, Weight loss seekers, Beauty enhancement enthusiasts, Wellness-focused professionals
    What sets them apart
    • Offers NAD+ infusion therapy as part of their IV service menu for anti-aging and wellness support.
    • Uses PNOĒ metabolic testing to support weight loss coaching and personalized wellness programs.
    • Combines IV therapy, injectables, laser treatments, and skincare under one roof for integrated anti-aging and beauty solutions.
    Medical SpaIV TherapyWeight LossCosmetic InjectablesAnti-Aging
    Phone(865) 218-9000
    Medispa At Choto
    Updated 4/15/26Learn More →
    85
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas; additional locations in Tennessee, Kentucky, Georgia, Mississippi, and Virginia
    ★★★★★5.0(162 Google reviews)

    TwelveStone Health Partners is a faith-based infusion center specializing in comprehensive chronic care management for patients with complex conditions including autoimmune diseases, cancer-related treatments, primary immunodeficiency, and rare genetic disorders. With over 35 years of experience, they provide individualized medication management and home infusion services in private suites equipped with free Wi-Fi, snacks, and beverages. Their clinical team works closely with healthcare providers to streamline referrals and medication protocols, emphasizing personalized patient care and family support throughout treatment.

    Ideal clients: Patients with chronic autoimmune or genetic conditions requiring ongoing infusion therapy, healthcare facilities seeking reliable infusion vendor partnerships, individuals seeking compassionate, faith-based medical care
    What sets them apart
    • Dedicated focus on complex, chronic conditions including autoimmune diseases, rare genetic disorders, and cancer-related treatments with individualized care protocols.
    • Private suites with free Wi-Fi, complimentary snacks and beverages, and chaplain services create a welcoming atmosphere designed to reduce patient anxiety.
    • Simple referral process with clinical liaisons and case management support that reduces patient wait times and medication errors for partnering healthcare organizations.
    Chronic Care InfusionsPrivate Treatment SuitesMedication ManagementFaith-Based CareComplex Conditions
    Phone(865) 333-4243
    TwelveStone Infusion Center Knoxville
    Updated 4/15/26Learn More →
    85
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    Score
    Knoxville, TN
    Serves Knoxville, Tennessee and surrounding East Tennessee areas
    ★★★★★5.0(154 Google reviews)

    Optimize U - Knoxville is a clinician-run hormone optimization and wellness clinic led by licensed healthcare professionals including a board-certified nurse practitioner, physician assistant, and MD. They specialize in hormone replacement therapy (HRT) for men and women, cryotherapy, and wellness services designed to help patients restore balance and improve quality of life. The clinic takes a personalized, patient-focused approach with medical staff on-site who listen to individual needs and customize treatment plans without pressure.

    Ideal clients: Adults seeking hormone optimization and HRT, individuals with perimenopause or menopause symptoms, people interested in athletic performance and recovery, wellness-focused patients wanting personalized medical care
    What sets them apart
    • All services are provided by licensed and trained healthcare professionals including MSN-certified nurse practitioners, physician assistants, and MDs who specialize in hormone optimization and wellness medicine.
    • The clinic takes time to understand each patient's unique needs and creates customized hormone optimization and wellness plans without pressure to pursue unwanted treatments.
    • Beyond hormone replacement therapy, the clinic offers cryotherapy and other wellness services to support recovery, pain management, and overall health optimization.
    Hormone OptimizationHRT ServicesCryotherapyWellness ClinicMedical Staff
    Phone(865) 766-2796
    Optimize U- Knoxville | Hormone Clinic
    Updated 4/15/26Learn More →
    85
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    Score
    Knoxville, TN
    Serves South Knoxville and Sevier County, Tennessee
    ★★★★★5.0(128 Google reviews)

    Peak IV Hydration is South Knoxville and Sevier County's premier IV therapy and wellness clinic offering customized intravenous hydration treatments with vitamins, minerals, amino acids, and electrolytes. Founded by medical professionals, they specialize in tailored IV treatments for athletic performance enhancement, recovery, hangover relief, migraine treatment, cold and flu support, weight loss, anti-aging, and overall wellness. The clinic also offers oxygen therapy and vitamin patch services in a relaxing spa-like setting with massage chairs and a welcoming atmosphere designed to make health optimization accessible and comfortable.

    Best for: Athletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, travelers and event attendees, individuals recovering from illness or hangovers, people seeking wellness optimization and anti-aging treatments
    What sets them apart
    • Founded and staffed by medical professionals including paramedics and nurses who bring clinical knowledge to personalized care and treatment protocols.
    • Beyond IV hydration, they offer oxygen therapy and vitamin patches, plus a spa-like experience with massage chairs and a comfortable environment for relaxation during treatment.
    • Custom IV cocktails formulated for specific needs including athletic performance, beauty and anti-aging, hangover recovery, migraine relief, and illness recovery.
    IV TherapyHydration WellnessAthletic PerformanceRecoveryVitamin Infusions
    Phone(865) 281-5263
    Peak IV Hydration-Knoxville
    Updated 4/15/26Learn More →
    85
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★5.0(109 Google reviews)

    Vital Hydration is a comprehensive wellness clinic in Knoxville specializing in IV hydration therapy, vitamin injections, and advanced recovery treatments. They offer a full spectrum of services including weight loss programs with GLP-1 and peptide therapy, testosterone replacement therapy, cryotherapy, infrared/red light sauna, and skincare solutions. Run by experienced healthcare professionals, they distinguish themselves through personalized nutrient delivery (100% absorption via IV versus 25-30% oral absorption), medical-grade treatments, and convenient mobile services that bring wellness directly to clients' homes or offices.

    Best for: Convenient at-home hydrationAthletic performance optimizationLuxury wellness experience
    Ideal clients: Busy professionals seeking energy recovery, athletes and fitness enthusiasts optimizing performance, individuals managing weight loss, clients seeking hormone balancing and anti-aging treatments
    What sets them apart
    • Brings IV hydration therapy and treatments directly to homes, offices, and events for maximum convenience, available upon request.
    • Licensed healthcare professionals administer 100% bioavailable IV formulations and injections, ensuring complete nutrient absorption compared to oral supplements.
    • Combines multiple therapies (IV, peptides, cryotherapy, hormone optimization, red light sauna, skincare) in one clinic to address energy, recovery, weight loss, and performance.
    IV TherapyWellness CenterWeight LossTRTRecovery
    Phone(865) 282-4634
    Vital Hydration
    Updated 4/15/26Learn More →
    85
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★5.0(96 Google reviews)

    Performance Medicine in North Knoxville offers comprehensive IV therapy services including NAD+ therapy, athletic performance IVs, and wellness infusions administered by medical professionals in a spa-like setting. They specialize in optimizing health and recovery for active individuals seeking performance enhancement and cellular rejuvenation. The clinic combines clinical expertise with a comfortable lounge environment to deliver personalized IV treatments.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, Active individuals seeking recovery optimization, Health-conscious professionals, Performance-focused clients
    What sets them apart
    • All IV therapies are administered by qualified medical professionals (RN/MD) ensuring safety and proper dosing for optimal results.
    • Offers specialized IV treatments including NAD+ therapy for cellular health, athletic performance IVs for recovery and endurance, and customized wellness infusions.
    • Private lounge setting designed for comfort and relaxation during treatment, differentiating the clinical experience from traditional medical facilities.
    IV TherapyNAD+ TherapyAthletic PerformanceWellness Infusions
    Phone(865) 381-7322
    Performance Medicine - Hotel Rd
    Updated 4/15/26Learn More →
    84
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    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★5.0(78 Google reviews)

    Culture Aesthetics & Wellness is a comprehensive med spa and wellness center in Knoxville offering aesthetic treatments, skincare services, massage therapy, and hair care under one roof. The facility combines medical-grade skincare and cosmetic procedures with traditional wellness services, providing clients with a full-spectrum approach to beauty and health. Their integrated team of licensed professionals delivers personalized treatments in a spa setting.

    Ideal clients: Health-conscious individuals seeking aesthetic treatments, people wanting integrated wellness services, clients looking for professional skincare and spa treatments
    What sets them apart
    • One location offers aesthetic treatments, skincare, massage, and hair services, allowing clients to address multiple wellness needs in a single visit.
    • Combines clinical skincare and cosmetic procedures with traditional wellness services for comprehensive aesthetic and health results.
    Med SpaSkincareMassage TherapyHair CareWellness
    Phone(865) 500-0101
    Culture Aesthetics & Wellness
    Updated 4/15/26Learn More →
    84
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    Score
    Knoxville, TN
    Serves Knoxville, Tennessee and nationwide (remote consultations available)
    ★★★★★4.9(598 Google reviews)

    RevitalyzeMD is a physician-owned and operated wellness center in Knoxville specializing in regenerative medicine, hormone replacement therapy (HRT), IV therapy, aesthetic treatments, and sexual wellness. Founded by Dr. Debra Durst, a double board-certified physician, the practice offers comprehensive services including skin rejuvenation, body contouring, peptide therapy, fitness and weight loss programs, and remote consultations for patients nationwide. RevitalyzeMD combines advanced regenerative science with aesthetic expertise to deliver personalized treatments designed to help patients feel better, look better, and optimize overall vitality.

    Best for: Convenient at-home hydration
    Ideal clients: Men seeking sexual health and testosterone optimization, women pursuing hormone balance and anti-aging, patients interested in IV therapy for wellness and athletic performance, individuals exploring regenerative medicine and aesthetic treatments
    What sets them apart
    • Founded and operated by Dr. Debra Durst, a double board-certified, fellowship-trained physician specializing in sexual health and wellness. Personalized treatment plans based on individual medical history and goals.
    • Offers integrated services spanning regenerative medicine, IV therapy, hormone optimization, aesthetic treatments, sexual wellness, peptides, and fitness/weight loss programs—not just IV therapy alone.
    • Provides remote HRT consultations, product shipping, and virtual wellness therapy for patients nationwide, while maintaining a luxury in-clinic destination experience in Knoxville.
    IV TherapyRegenerative MedicineHRTAestheticsWellness
    Phone(865) 293-5828
    RevitalyzeMD
    Updated 4/15/26Learn More →
    84
    Lantern
    Score
    Powell, TN · 6 mi from Knoxville
    Serves Powell, TN and surrounding areas
    ★★★★★5.0(60 Google reviews)

    Thriving to a New You is a wellness spa in Powell, TN offering IV therapy, NAD+ therapy, weight loss programs, and other rejuvenation services designed to optimize health and vitality. The business specializes in customized IV infusions and wellness treatments that address energy, recovery, and overall wellness goals. They provide a professional, spa-like setting with medical staff oversight to ensure safe, effective treatments.

    Best for: Advanced longevity therapyAthletic performance optimizationLuxury wellness experience
    Ideal clients: Health-conscious individuals seeking IV wellness treatments, Athletes and fitness enthusiasts, People pursuing weight loss support, Anyone interested in NAD+ and anti-aging therapies
    What sets them apart
    • Tailored IV therapy treatments designed for individual health goals, from energy and immune support to athletic performance and recovery.
    • Offers NAD+ infusions to support cellular health, energy production, and anti-aging wellness objectives.
    • Provides treatments in a relaxing, spa-like setting with medical oversight for optimal safety and comfort.
    IV TherapyNAD+ TherapyWellness SpaWeight LossHealth Optimization
    Phone(865) 232-3169
    Thriving to a New You
    Updated 4/15/26Learn More →
    84
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★4.9(269 Google reviews)

    Prime IV Hydration & Wellness in Knoxville offers IV therapy infusions designed to boost hydration, energy, immunity, athletic performance, anti-aging, and overall wellness. Their menu includes signature treatments like the Myers' Cocktail, Rehydrate, Athletic Performance, Immunity Boost, and Anti-Aging infusions, plus customizable boosts and quick injection therapies. Clients receive personalized consultations to design treatment plans tailored to their health goals, and can relax in state-of-the-art massage chairs during 30-45 minute sessions. They offer flexible membership plans, accept HSA/FSA funds, and provide both walk-in and appointment-based access.

    Best for: Athletic performance optimizationLuxury wellness experience
    Ideal clients: Fitness enthusiasts seeking athletic recovery, professionals managing fatigue and stress, beauty-conscious individuals wanting anti-aging benefits, those with chronic dehydration or nutrient deficiencies
    What sets them apart
    • Each client receives a personalized consultation to design an optimization program based on their specific symptoms and health objectives, with ongoing adjustments to ensure results.
    • Treatments are administered while clients recline in heated, full-body massage chairs featuring percussion, kneading, vibration, and rolling functions for maximum comfort during infusion.
    • Three tiered membership plans (Essentials, Transformation, Prime) provide significant savings, VIP status, massage chair access, and discounted add-ons for regular clients.
    IV TherapyWellness InfusionsAthletic RecoveryAnti-AgingHydration Boost
    Phone(865) 302-3182
    Prime IV Hydration & Wellness - Knoxville
    Updated 4/15/26Learn More →
    84
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★4.9(258 Google reviews)

    Old City Medspa is a full-service medical spa in downtown Knoxville offering cosmetic injectables, skin rejuvenation treatments, laser therapies, body contouring, pelvic floor strength services, and wellness programs. Led by Medical Director Mark Davenport, MD, the clinic combines professional expertise with affordable membership options to make premium anti-aging and aesthetic services accessible. Their team specializes in Botox, Ultherapy, Emsculpt, vampire facials, laser hair removal, chemical peels, and personalized skincare solutions.

    Best for: Luxury wellness experience
    Ideal clients: Anti-aging seekers, first-time cosmetic treatment clients, busy professionals, people seeking affordable membership-based access to premium medspa services
    What sets them apart
    • Led by Mark Davenport, MD, ensuring clinical expertise and safety across all cosmetic and wellness treatments.
    • Platinum, Gold, and Spa Club memberships offering 20-50% off services, making premium treatments more affordable for regular clients.
    • One-stop destination for injectables, skin treatments, body contouring, laser therapies, and wellness services rather than specialized single-service clinics.
    Med SpaAnti-AgingCosmetic InjectablesLaser TreatmentsSkin Rejuvenation
    Phone(865) 247-5057
    Old City Medspa
    Updated 4/15/26Learn More →
    83
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★5.0(36 Google reviews)

    Jacobs IV Hydration is a wellness center in Knoxville specializing in intravenous hydration and nutrient therapy. They offer customized IV infusions designed to boost energy, support athletic performance, enhance recovery, and promote overall wellness. Their medical staff administers treatments in a comfortable, professional setting tailored to individual health goals.

    Best for: Athletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, busy professionals seeking wellness optimization, post-event recovery, individuals focused on preventive health
    What sets them apart
    • Tailored infusion protocols designed for specific wellness goals, from hydration and energy to athletic performance and recovery.
    • Treatments administered by qualified medical professionals in a clinical yet comfortable wellness environment.
    IV TherapyHydrationWellnessNutrient InfusionsRecovery
    Phone(865) 392-1791
    Jacobs IV Hydration
    Updated 4/15/26Learn More →
    83
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★4.9(77 Google reviews)

    Performance Medicine in Knoxville offers comprehensive wellness and aesthetic services including IV therapy, medical-grade skincare, and performance optimization treatments. Led by experienced medical professionals, they combine evidence-based medicine with advanced therapies to help patients achieve their health and wellness goals. Their focus on personalized care and cutting-edge treatments makes them a standout provider for those seeking results-driven medical wellness.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes and active individuals, professionals seeking wellness optimization, those pursuing aesthetic improvements, health-conscious individuals
    What sets them apart
    • Licensed medical professionals administer all treatments, ensuring safety and efficacy in IV therapy, skincare, and wellness services.
    • Combines IV therapy, aesthetic treatments, and performance optimization to address health goals comprehensively rather than in isolation.
    • Uses scientifically-backed protocols and premium products for measurable results in skin health, energy, and overall wellness.
    IV TherapyMedical AestheticsWellnessSkincarePerformance Medicine
    Phone(865) 249-7672
    Performance Medicine - Kingston Pike
    Updated 4/15/26Learn More →
    83
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★4.9(76 Google reviews)

    Hydr865 is an IV infusion therapy and weight loss wellness center in Knoxville offering customized intravenous treatments designed to boost energy, immunity, athletic performance, and overall wellness. Their medical staff administers a range of IV therapies tailored to individual health goals, complemented by comprehensive weight loss programs. Located at University Commons, Hydr865 combines clinical expertise with a spa-like environment to deliver results-focused wellness solutions.

    Best for: Athletic performance optimization
    Ideal clients: Active individuals seeking performance enhancement, people pursuing weight loss with professional support, wellness-focused clients wanting IV nutrient therapy, athletes in recovery
    What sets them apart
    • Licensed medical professionals including RNs and MDs administer all IV therapies, ensuring safety and proper dosing for each client's health goals.
    • Combines IV infusion therapy with structured weight loss programs, allowing clients to address multiple wellness objectives through coordinated treatment plans.
    • Offers athletic performance IVs and recovery-focused formulations designed for active individuals seeking enhanced energy and faster recuperation.
    IV TherapyWeight Loss ProgramsWellness CenterMedical StaffKnoxville
    Phone(865) 398-4361
    Hydr865 : IV Infusion Therapy & Weight Loss
    Updated 4/15/26Learn More →
    83
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    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★5.0(35 Google reviews)

    Valencia Medspa in Knoxville offers a comprehensive range of medical spa and skincare services, including facials, chemical peels, microneedling, laser treatments, and injectables administered by licensed medical professionals. As part of the Valencia network, they combine clinical expertise with spa-quality care to address anti-aging, skin rejuvenation, and aesthetic concerns. Their medically-supervised approach ensures safe, effective treatments tailored to individual skin types and goals.

    Ideal clients: Anti-aging seekers, individuals with skin concerns (acne, pigmentation, texture), cosmetic enhancement clients, busy professionals wanting medical-grade results
    What sets them apart
    • All treatments are administered by or under the supervision of licensed medical professionals, ensuring clinical safety and efficacy beyond typical day spas.
    • Offers both non-invasive treatments (facials, chemical peels, laser) and injectables in one location, allowing clients to customize their skincare and aesthetic goals.
    Medical SpaSkincareInjectablesLaser TreatmentsAnti-Aging
    Phone(865) 333-6554
    Valencia Medspa
    Updated 4/15/26Learn More →
    83
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    Knoxville, TN
    Serves Knoxville, Tennessee and surrounding areas
    ★★★★★4.9(74 Google reviews)

    Drip into Wellness is a wellness center in Knoxville specializing in IV therapy treatments designed to boost energy, immunity, athletic performance, and overall health. They offer a range of IV formulations tailored to individual wellness goals, from hydration and nutrient replenishment to specialized recovery and anti-aging treatments. Their experienced medical staff administers treatments in a comfortable, spa-like setting focused on personalized wellness care.

    Best for: Athletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, busy professionals seeking wellness optimization, individuals focused on preventive health, those recovering from illness or fatigue
    What sets them apart
    • Drip into Wellness brings IV therapy treatments directly to clients' homes or offices for added convenience and comfort.
    • Medical staff work with each client to design IV formulations matched to their specific wellness goals, whether athletic recovery, immunity support, or energy enhancement.
    • Treatments are administered in a professional, relaxing setting that prioritizes client comfort and wellness experience.
    IV TherapyWellness CenterMobile ServiceKnoxville
    Phone(865) 214-6064
    Drip into Wellness
    Updated 4/15/26Learn More →
    82
    Lantern
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    Maryville, TN · 16 mi from Knoxville
    Serves Maryville, TN and surrounding Smoky Mountain communities
    ★★★★★5.0(29 Google reviews)

    Smoky Mountain Hydration is a wellness spa in Maryville, TN specializing in IV therapy treatments designed to boost energy, immunity, and athletic performance. They offer customized IV infusions administered by medical staff in a relaxing spa setting, with options for hydration therapy, vitamin supplementation, and specialized wellness protocols. Whether you're looking to recover from illness, enhance athletic performance, or simply optimize your health, their team provides personalized IV therapy solutions.

    Best for: Athletic performance optimizationLuxury wellness experience
    Ideal clients: Athletes seeking recovery, health-conscious individuals, those with chronic fatigue or immunity concerns, wellness enthusiasts
    What sets them apart
    • IV therapies are administered by qualified medical professionals in a clinical spa setting, ensuring safety and proper administration.
    • Treatments are tailored to individual wellness goals, from athletic recovery to immune support to general hydration optimization.
    IV TherapyWellness SpaHydrationHealth OptimizationMaryville
    Phone(865) 233-8330
    Smoky Mountain Hydration
    Updated 4/15/26Learn More →
    81
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★4.9(39 Google reviews)

    Happy Health and Wellness Clinic in Knoxville offers comprehensive wellness services including IV therapy, nutritional counseling, and holistic health treatments. Their team of medical professionals focuses on preventive care and optimizing patient wellness through personalized treatment plans. They specialize in helping patients achieve better health outcomes through evidence-based integrative medicine.

    Ideal clients: Health-conscious individuals seeking preventive care, patients wanting integrative wellness approaches, people looking for nutritional counseling and IV therapy
    What sets them apart
    • Licensed medical professionals oversee all treatments and therapies.
    • Combines traditional medicine with holistic wellness practices for comprehensive care.
    • Customized wellness programs tailored to individual patient needs and health goals.
    IV TherapyWellnessHolistic HealthKnoxville
    Happy Health and Wellness Clinic
    Updated 4/15/26Learn More →
    81
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★4.9(37 Google reviews)

    865 Wellness + Ketamine is a medical wellness clinic in Knoxville offering ketamine-assisted therapy, IV therapy, and holistic wellness treatments. Led by experienced medical professionals, they specialize in mental health conditions including depression, anxiety, PTSD, and chronic pain management through evidence-based ketamine protocols combined with therapeutic support. The clinic integrates conventional medical care with wellness services in a spa-like setting designed for patient comfort and healing.

    Best for: Advanced longevity therapy
    Ideal clients: Individuals with treatment-resistant depression or anxiety, PTSD sufferers, chronic pain patients, people seeking alternative mental health treatments
    What sets them apart
    • Specializes in medical-grade ketamine protocols for treatment-resistant depression, anxiety, PTSD, and chronic pain, administered by licensed medical professionals.
    • Combines IV therapy, ketamine treatment, and therapeutic support in a spa-like clinical environment to address both mental health and overall wellness.
    • Staffed by experienced medical professionals who oversee all treatments, ensuring safety and efficacy for patients seeking advanced mental health solutions.
    Ketamine TherapyIV TherapyMental HealthWellness ClinicPain Management
    Phone(865) 805-3118
    865 Wellness + Ketamine
    Updated 4/15/26Learn More →
    81
    Lantern
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    Concord, TN · 13 mi from Knoxville
    Serves Concord, Tennessee and surrounding areas
    ★★★★★4.9(37 Google reviews)

    VibrantMe Wellness Clinic in Concord offers comprehensive wellness services focused on rejuvenation and holistic health. Specializing in spa treatments and wellness therapies, they provide a calming environment designed to support physical and mental well-being. Their team is dedicated to helping clients achieve balance through personalized wellness experiences.

    Ideal clients: Individuals seeking relaxation and wellness treatments, people interested in holistic health approaches, those looking for spa-based rejuvenation
    What sets them apart
    • VibrantMe specializes in spa-based wellness treatments in a dedicated facility designed for relaxation and rejuvenation.
    • They emphasize comprehensive wellness services that address both physical and mental well-being.
    Wellness SpaHolistic HealthConcord TNRelaxationSelf-Care
    Phone(865) 288-0450
    VibrantMe Wellness Clinic
    Updated 4/15/26Learn More →
    81
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★4.8(84 Google reviews)

    Forum Health Knoxville is an integrative medicine clinic offering IV therapy, NAD+ treatments, weight loss programs, and functional medicine services. Their medical team combines conventional and alternative approaches to address chronic conditions, optimize athletic performance, and support overall wellness. They specialize in personalized IV protocols and same-day appointment availability for patients seeking comprehensive, science-based integrative care.

    Best for: Convenient at-home hydrationAdvanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes seeking performance optimization, individuals with chronic health conditions, patients interested in preventive wellness, weight loss seekers
    What sets them apart
    • Offers flexible scheduling with same-day availability for IV therapy and infusion treatments without lengthy wait times.
    • Licensed RNs and medical doctors administer treatments, ensuring safe, professional care for all IV protocols.
    • Combines IV therapy, NAD+ treatments, weight loss programs, and functional medicine in one clinic for coordinated patient care.
    IV TherapyNAD+ TherapyIntegrative MedicineFunctional MedicineWellness
    Phone(865) 675-9355
    Forum Health Knoxville Integrative Medicine
    Updated 4/15/26Learn More →
    81
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    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★5.0(107 Google reviews)

    BioworX Knoxville is a wellness and recovery center offering cryotherapy, IV therapy, and other biohacking services designed to enhance athletic performance, speed recovery, and support overall wellness. Located in Knoxville, the facility combines advanced recovery technologies with professional staff to help clients optimize their physical and mental health through science-backed treatments.

    Best for: Athletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, Active adults seeking recovery optimization, Wellness-focused individuals, People with demanding physical lifestyles
    What sets them apart
    • Offers comprehensive recovery solutions including cryotherapy and IV therapy in one location, allowing clients to combine treatments for enhanced results.
    • Specializes in athletic recovery and performance optimization, making it ideal for serious athletes and fitness enthusiasts seeking science-backed enhancement methods.
    • Operates from a dedicated wellness facility with trained staff, ensuring safe administration of advanced recovery therapies.
    CryotherapyIV TherapyWellness RecoveryAthletic PerformanceBiohacking
    Phone(865) 240-4639
    BioworX Knoxville
    Updated 4/15/26Learn More →
    81
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★4.9(29 Google reviews)

    Regener8 Health and Wellness is a medical wellness center in Knoxville offering IV therapy, NAD+ therapy, weight loss programs, and athletic performance optimization. Founded by healthcare professionals, they combine cutting-edge regenerative medicine with personalized wellness plans to help clients achieve peak health and vitality. Their comprehensive approach addresses everything from recovery and longevity to energy optimization and athletic performance.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes seeking performance enhancement, individuals pursuing anti-aging wellness, weight loss clients, wellness-focused professionals
    What sets them apart
    • Offers NAD+ therapy designed to boost cellular energy, support recovery, and enhance overall vitality.
    • Provides multiple IV therapy options including athletic performance, weight loss support, and general wellness infusions tailored to individual health goals.
    • Medical professionals on staff ensure safe administration and personalized treatment plans based on individual health needs.
    IV TherapyNAD+ TherapyWellnessRegenerative MedicineHealth Optimization
    Phone(865) 617-2378
    Regener8 Health and Wellness
    Updated 4/15/26Learn More →
    80
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★5.0(56 Google reviews)

    IVX Health Infusion Center in Knoxville offers IV therapy treatments designed to support wellness, athletic performance, and recovery. Located on Parkside Drive, their medical team provides customized infusion services in a professional clinical setting, serving patients seeking IV hydration, nutrient therapies, and specialized wellness protocols.

    Best for: Athletic performance optimization
    Ideal clients: Athletes and active individuals, Wellness-focused adults, Those seeking IV hydration and nutrient support
    What sets them apart
    • Licensed medical professionals administer all IV therapies in a clinical setting, ensuring safety and proper protocol adherence.
    • IVX Health tailors infusion protocols to individual wellness goals, whether for hydration, nutrient replenishment, or athletic recovery.
    IV TherapyInfusion CenterWellnessMedical ClinicKnoxville
    Phone(865) 205-9590
    IVX Health Infusion Center - Parkside Dr
    Updated 4/15/26Learn More →
    80
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★5.0(54 Google reviews)

    Lifespring Health Center is a comprehensive wellness clinic in Knoxville offering IV therapy, NAD+ treatments, weight loss programs, and athletic performance optimization. Led by medical professionals, the center combines modern wellness services with evidence-based medicine to help clients achieve their health goals through personalized treatment plans.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, individuals pursuing weight loss, busy professionals seeking wellness optimization, clients interested in NAD+ and IV therapy
    What sets them apart
    • Services administered by qualified medical professionals (RN/MD) ensuring safe, clinical-grade treatments.
    • Offers multiple service lines including IV therapy, NAD+ therapy, weight loss support, and athletic performance optimization in one integrated facility.
    • Each client receives individualized assessments and customized protocols tailored to their specific health and performance goals.
    IV TherapyNAD+ TreatmentWellness ClinicWeight LossAthletic Performance
    Phone(865) 229-4259
    Lifespring Health Center
    Updated 4/15/26Learn More →
    79
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★4.9(89 Google reviews)

    IVX Health Infusion Center in Knoxville offers IV therapy treatments including hydration, NAD+ therapy, athletic performance enhancement, and wellness infusions administered by medical staff in a comfortable clinical setting. Located on Highland Pl Way, they provide same-day appointments and customized IV protocols to support recovery, energy, athletic performance, and overall wellness goals.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes seeking performance enhancement, individuals pursuing anti-aging wellness, busy professionals needing quick hydration and energy support, patients interested in NAD+ therapy
    What sets them apart
    • All IV infusions are administered by licensed medical professionals, ensuring safety and proper protocol adherence.
    • Offers specialized treatments including NAD+ therapy, athletic performance IVs, hydration therapy, and customized wellness infusions tailored to individual goals.
    • Flexible appointment availability including same-day bookings for patients seeking quick access to IV therapy services.
    IV TherapyNAD+ TherapyWellness InfusionsMedical StaffSame-Day Appointments
    Phone(865) 243-8100
    IVX Health Infusion Center - Highland Pl Way
    Updated 4/15/26Learn More →
    77
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, TN and surrounding areas
    ★★★★★4.7(28 Google reviews)

    IVX Health Infusion Center in Knoxville offers IV therapy services in a professional medical setting with experienced clinical staff. They provide various IV treatments designed to support wellness, hydration, and overall health outcomes. The center serves patients seeking IV-based therapies in a comfortable, clinical environment.

    Ideal clients: Wellness-focused individuals, patients seeking IV hydration therapy, those interested in nutrient infusion treatments
    What sets them apart
    • Licensed nursing and medical professionals administer all IV therapies, ensuring safety and proper treatment protocols.
    • Specialized facility designed specifically for IV therapy services with clinical-grade equipment and a professional medical environment.
    IV TherapyInfusion CenterWellnessMedical ServicesKnoxville
    Phone(865) 862-4557
    IVX Health Infusion Center - Kingston Pike
    Updated 4/15/26Learn More →
    73
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, Tennessee and surrounding East Tennessee communities
    ★★★★☆4.3(78 Google reviews)

    Revitalist Ketamine Therapy Knoxville is a medical clinic specializing in ketamine-assisted therapy for treatment-resistant depression, anxiety, PTSD, and chronic pain. Led by experienced medical professionals, they offer supervised ketamine infusions in a clinical setting with personalized treatment plans designed to provide rapid symptom relief for patients who haven't responded to traditional medications. The clinic combines evidence-based ketamine protocols with comprehensive mental health support to address conditions that often require alternative therapeutic approaches.

    Ideal clients: Patients with treatment-resistant depression, Individuals with chronic pain unresponsive to conventional treatment, People with PTSD or severe anxiety seeking rapid relief
    What sets them apart
    • Medical clinic dedicated exclusively to ketamine-assisted therapy, using evidence-based protocols specifically designed for rapid symptom relief in treatment-resistant conditions.
    • All ketamine infusions administered by qualified medical staff in a controlled clinical environment, ensuring safety and optimal therapeutic outcomes.
    • Treats multiple conditions including depression, anxiety, PTSD, and chronic pain with personalized treatment plans tailored to individual patient needs.
    Ketamine TherapyMental HealthDepression TreatmentPain ManagementMedical Clinic
    Phone(833) 633-1576
    Revitalist Ketamine Therapy Knoxville
    Updated 4/15/26Learn More →
    72
    Lantern
    Score
    Knoxville, TN
    Serves Knoxville, Tennessee and surrounding areas
    ★★★★☆4.3(49 Google reviews)

    The Functional Medicine MD offers IV therapy and comprehensive functional medicine services in Knoxville, treating the root causes of illness rather than just symptoms. Dr. Arin Vaziri and his team specialize in customized IV nutritional therapies, wellness optimization, and chronic disease management using evidence-based functional medicine approaches. They serve patients seeking preventative care, performance optimization, and solutions for complex health conditions.

    Ideal clients: Patients seeking preventative wellness, individuals with chronic health conditions, athletes pursuing performance optimization, wellness-focused professionals
    What sets them apart
    • Focuses on identifying and treating underlying causes of illness rather than managing symptoms alone, using functional medicine principles.
    • Offers personalized IV nutritional protocols tailored to individual patient needs and health goals.
    • Combines IV therapy with functional medicine consultation, lifestyle optimization, and preventative health strategies.
    IV TherapyFunctional MedicineWellnessNutritional SupportPreventative Care
    Phone(865) 275-5024
    The Functional Medicine MD: IV Therapy and Functional Medicine
    Updated 4/15/26Learn More →

    Frequently Asked Questions

    Which IV therapy clinic is top-ranked in Knoxville?

    The Wellness Room is Knoxville's top-ranked IV therapy and wellness clinic with a Lantern Score of 85.64/100 and 491 five-star reviews. Owned by board-certified Nurse Practitioner Stephanie Snowden-Harman with over 10 years of clinical experience, it specializes in natural-looking aesthetic results and non-surgical skin rejuvenation.

    What IV therapy options are available for athletes in Knoxville?

    Athletes can choose from multiple specialized providers including Prime IV Hydration & Wellness - Farragut (Lantern Score: 85.52/100), Peak IV Hydration (84.91/100), BioworX Knoxville (81.13/100), and Performance Medicine locations, all offering customized athletic performance, recovery, and enhancement IV treatments.

    Which clinics offer hormone optimization and HRT services?

    Optimize U - Knoxville (Lantern Score: 85.07/100) is a clinician-run hormone optimization clinic led by a board-certified nurse practitioner, physician assistant, and MD, specializing in perimenopause, menopause, and athletic performance. RevitalyzeMD (83.95/100) also offers comprehensive hormone replacement therapy for both men and women.

    Are there IV therapy clinics offering weight loss programs in Knoxville?

    Yes, several clinics combine IV therapy with weight loss support, including Medispa At Choto (Lantern Score: 85.30/100) with metabolic testing, Vital Hydration (84.75/100), Thriving to a New You (83.88/100), and Hydr865 (82.64/100), all offering customized weight loss coaching alongside nutrient infusions.

    Which clinic specializes in ketamine therapy for depression and anxiety?

    865 Wellness + Ketamine (Lantern Score: 81.23/100) specializes in ketamine-assisted therapy for treatment-resistant depression, anxiety, PTSD, and chronic pain. Revitalist Ketamine Therapy Knoxville (72.81/100) also offers ketamine-assisted therapy services, though with a lower Lantern Score.

    What specialized IV therapy options exist beyond standard hydration?

    Knoxville clinics offer NAD+ therapy (available at Forum Health, Lifespring Health Center, and Thriving to a New You), regenerative medicine services (RevitalyzeMD, Lantern Score: 83.95/100), cryotherapy combined with IV therapy (BioworX, 81.13/100), and specialized athletic performance and anti-aging formulations across 31 local providers.

    This directory of iv therapy & wellness clinics local businesses serving Knoxville, TN is maintained by Lantern. Rankings are determined by the Lantern Score — not advertising or payment for placement. Learn how it works. Last updated April 15, 2026. To claim or update a listing, contact us.