LanternCaliforniaIrvineWellness & HealthIV Therapy & Wellness Clinics

    Best IV Therapy & Wellness Clinics in Irvine, California

    Areas served: Irvine, CA and surrounding Orange County

    30 local businessesRanked by Lantern Score — a measure of reputation and business quality. We don't accept payment for placement.
    Updated April 15, 2026

    Irvine hosts a concentrated network of IV therapy and wellness clinics, reflecting the city's health-conscious population and proximity to major medical institutions in Orange County. This directory covers clinics offering vitamin infusions, hydration therapy, NAD+ treatments, and wellness protocols throughout Irvine's business districts and medical corridors. Providers have been evaluated based on medical oversight, treatment protocols, facility standards, and patient outcomes.

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    Brea, CA · 17 mi from Irvine
    Serves Brea, CA and surrounding Orange County communities
    ★★★★★5.0(164 Google reviews)

    Prime IV Hydration & Wellness in Brea specializes in IV vitamin infusions and wellness treatments designed to help clients look, feel, and perform better. Their service menu includes rehydration, athletic performance, anti-aging, hangover recovery, immunity boost, weight loss, and specialized drips like Myers' Cocktail and jetlag recovery. They also offer injection therapies (B12, vitamin D, biotin), customizable IV boosts (beauty, liver detox, amplifiers), and amenities like state-of-the-art massage chairs and medical-grade oxygen therapy. The clinic accepts HSA/FSA pre-tax dollars and provides personalized consultation to design custom wellness programs based on individual health goals.

    Best for: Athletic performance optimizationLuxury wellness experience
    Ideal clients: Fitness enthusiasts, frequent travelers, anti-aging seekers, busy professionals needing quick wellness boosts, athletes in recovery
    What sets them apart
    • Offers 10+ targeted IV treatments including athletic performance, weight loss, anti-aging, and altitude sickness recovery, plus customizable boost packages with glutathione and liver detox options.
    • Treatments administered in state-of-the-art heated massage chairs with percussion and kneading, plus optional medical-grade oxygen therapy to enhance the wellness experience.
    • Membership programs include your choice of primary drip, B12/Lipolean shots, VIP massage chair access, oxygen therapy, and discounts on additional treatments, allowing clients to optimize wellness at their own pace.
    IV TherapyWellnessHydrationVitamin InfusionsAnti-Aging
    Phone(714) 646-1865
    Prime IV Hydration & Wellness - Brea
    Updated 4/15/26Learn More →
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    Huntington Beach, CA · 12 mi from Irvine
    Serves Huntington Beach, CA and surrounding Orange County communities
    ★★★★★5.0(111 Google reviews)

    The DRIPBaR Huntington Beach is a wellness center specializing in intravenous therapy, including IV hydration, NAD+ therapy, athletic performance IVs, and weight loss programs. Located on Beach Boulevard, they offer a spa-like setting with medical staff on-site to administer customized IV treatments designed to boost energy, recovery, and overall wellness. Whether you're an athlete optimizing performance, someone seeking anti-aging benefits, or looking for hydration support, The DRIPBaR provides a professional, upscale experience tailored to individual health goals.

    Best for: Advanced longevity therapyAthletic performance optimizationLuxury wellness experience
    Ideal clients: Athletes and fitness enthusiasts, individuals seeking anti-aging and wellness optimization, busy professionals needing quick hydration and energy boosts, weight loss seekers
    What sets them apart
    • Offers multiple IV therapy options including hydration, NAD+ therapy, athletic performance IVs, and weight loss programs—not just one service.
    • All treatments administered by qualified medical professionals in a clean, professional setting.
    • Combines clinical excellence with a luxurious, relaxing atmosphere for a premium wellness experience.
    IV TherapyWellness CenterNAD+ TherapyHydrationHealth
    Phone(714) 516-7350
    The DRIPBaR Huntington Beach
    Updated 4/15/26Learn More →
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    Irvine, CA
    Serves Irvine, CA and surrounding Orange County
    ★★★★★5.0(101 Google reviews)

    OHMI Anti-Aging Center is an award-winning regenerative aesthetics and wellness clinic in Irvine founded and directed by Dr. Maxwell Jen, MD, MBA, a quadruple board-certified physician specializing in anti-aging medicine. They offer a comprehensive 360-degree treatment system spanning skin rejuvenation, face contouring, body sculpting, IV therapy, weight management, and non-surgical hair restoration—all designed around personalized medical wellness plans that optimize health alongside aesthetic results. With over 10 years of experience and 2,000+ clients served, OHMI combines advanced technology (including AI skin analysis) with clinical expertise to deliver natural, long-lasting rejuvenation.

    Best for: Luxury wellness experience
    Ideal clients: Anti-aging seekers, aesthetic rejuvenation patients, medically supervised weight management, wellness-focused individuals, non-surgical beauty enhancement
    What sets them apart
    • Led by Dr. Maxwell Jen, a quadruple board-certified physician specializing in regenerative anti-aging medicine, ensuring all treatments are grounded in clinical expertise and medical safety.
    • Offers a comprehensive, multi-phase approach (Correct, Prevent, Empower) that coordinates skin, body, face, hair, and wellness services into a cohesive rejuvenation plan tailored to each client's unique needs.
    • Uses AI-integrated multi-spectral skin imaging to detect subsurface damage and objectively measure skin health before designing personalized treatment protocols.
    Anti-AgingRegenerative AestheticsIV TherapyMedical WellnessNon-Invasive
    Phone(949) 238-7716
    Websiteohmimd.com
    Ohmi Anti-Aging Center
    Updated 4/15/26Learn More →
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    Newport Beach, CA · 6 mi from Irvine
    Serves Orange County and parts of Los Angeles County, CA
    ★★★★★5.0(94 Google reviews)

    IV ME UP is a mobile IV therapy service based in Newport Beach, CA, delivering wellness treatments directly to clients' homes, offices, and hotels throughout Orange County and parts of Los Angeles County. Founded by licensed medical professionals, the company offers a comprehensive range of IV drips (including NAD+, Myers Cocktail, Athletic Recovery, Beauty Booster, and Immune Warrior), injection therapies, weight loss programs, and personalized wellness protocols—all administered by licensed nurses under physician supervision. With same-day availability, 7 days a week, and a focus on evidence-based formulations, IV ME UP combines medical expertise with the convenience of in-home treatment.

    Best for: Convenient at-home hydrationAdvanced longevity therapyAthletic performance optimization
    Ideal clients: Busy professionals, post-workout athletes, event preparation, hangover recovery, wellness enthusiasts, immune support seekers
    What sets them apart
    • All IV therapies are delivered directly to your location—home, office, or hotel—eliminating the need to visit a clinic. Sessions take 45-60 minutes and include full nurse setup, administration, and monitoring.
    • All treatments are administered by licensed registered nurses with on-call physician, PA, or NP oversight. Medical staff reviews your health history and tailors formulations to your specific needs.
    • IV ME UP accommodates urgent wellness needs with same-day booking based on nurse availability, making it ideal for hangover recovery, illness support, or event preparation.
    Mobile IV TherapyNAD+ TreatmentsWellness RecoveryLicensed NursesOrange County
    Phone(949) 478-5188
    Websiteivmeup.com
    Iv Me Up
    Updated 4/15/26Learn More →
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    Huntington Beach, CA · 10 mi from Irvine
    Serves Huntington Beach, CA and surrounding Orange County areas
    ★★★★★5.0(74 Google reviews)

    WeVitalize is a physician-designed wellness center in Huntington Beach led by Dr. Zain Vally, MD, specializing in IV therapy, cosmetic treatments, and preventative wellness services. The clinic offers IV therapies including NAD+, immunity, hangover, and B12 shots; cosmetic injectables like Botox and fillers; skincare treatments including Hydrafacials and microneedling; and wellness services such as infrared sauna, compression therapy, and health coaching. Known for personalized attention and experienced medical professionals, WeVitalize combines cutting-edge occupational medicine with aesthetic and preventative care.

    Best for: Advanced longevity therapyLuxury wellness experience
    Ideal clients: Health-conscious professionals seeking preventative wellness, individuals interested in cosmetic injectables and skincare, athletes and fitness enthusiasts pursuing recovery optimization, people exploring NAD+ therapy
    What sets them apart
    • Founded and directed by Dr. Zain Vally, MD, an Internal Medicine specialist with over a decade of experience in occupational medicine, ensuring medical-grade protocols and personalized treatment planning.
    • Combines IV therapy, cosmetic injectables, skincare treatments, infrared sauna, compression therapy, and health coaching in one integrated facility for full-spectrum wellness.
    • Specializes in NAD+ therapy alongside immune-boosting, energy, and recovery-focused IV formulations delivered by experienced medical professionals.
    IV TherapyWellness CenterCosmetic TreatmentsInfrared SaunaMedical Spa
    Phone(714) 378-8660
    WeVitalize
    Updated 4/15/26Learn More →
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    Diamond Bar, CA · 22 mi from Irvine
    Serves Diamond Bar, Los Angeles, Brea, Buena Park, CA
    ★★★★★5.0(69 Google reviews)

    Mega Wellness Clinic is a functional and internal medicine clinic offering IV vitamin therapy, bioidentical hormone replacement therapy (BHRT), lab testing, and physician consultations. Led by a dual-trained doctor experienced in both conventional and functional medicine, they take a holistic approach to help patients age healthily and address root causes of health conditions. They also provide doctor-recommended supplements and Obagi skincare products, with multiple locations across Southern California including Diamond Bar, Los Angeles, Brea, and Buena Park.

    Ideal clients: Patients seeking preventive wellness and anti-aging care, individuals going through menopause or andropause, those recovering from illness or fatigue, patients interested in functional medicine approach to health
    What sets them apart
    • Doctor trained in both conventional internal medicine and functional medicine, enabling a personalized approach that combines both disciplines for comprehensive care.
    • Beyond IV therapy, the clinic offers functional medicine consultations, bioidentical hormone replacement therapy, in-house lab testing, and curated supplements to support long-term health goals.
    • Four locations across Southern California (Diamond Bar, Los Angeles, Brea, Buena Park) with online appointment booking for easy access.
    IV TherapyFunctional MedicineWellness ClinicBHRTLab Testing
    Phone(909) 274-7286
    Mega IV Therapy Diamond Bar
    Updated 4/15/26Learn More →
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    Irvine, CA
    Serves Irvine and Tustin, CA
    ★★★★★5.0(49 Google reviews)

    Biolite Wellness is a comprehensive med spa in Irvine, CA founded by a Harvard and Stanford-trained physician-scientist director. They offer a holistic approach to wellness combining medical weight loss, injectables (Botox, fillers, Sculptra), laser skin rejuvenation, RF microneedling, body contouring (Emsculpt Neo), hair restoration, and preventive health screenings. The facility specializes in personalized aesthetic and wellness programs designed to prevent disease, improve longevity, and help clients achieve both health and timeless beauty goals.

    Ideal clients: Health-conscious professionals seeking preventive wellness, individuals pursuing medical weight loss, patients wanting aesthetic treatments with clinical oversight, busy professionals valuing concierge service
    What sets them apart
    • Led by a physician-scientist with elite medical training, ensuring clinical expertise and evidence-based treatment protocols.
    • Combines aesthetic treatments with medical weight loss, preventive health screening, body composition analysis, and personalized fitness planning for whole-body wellness.
    • Offers tiered membership options (Gold, Platinum, Diamond) with monthly wellness credits and concierge access to prioritize client convenience.
    Med SpaAesthetic MedicineWeight LossSkin RejuvenationWellness
    Phone(949) 800-8685
    Biolite Wellness
    Updated 4/15/26Learn More →
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    Anaheim, CA · 13 mi from Irvine
    Serves Anaheim, Orange County, CA
    ★★★★★5.0(49 Google reviews)

    Orange County IV Lounge is a wellness center in Anaheim specializing in personalized IV therapy, intramuscular (IM) shots, and biomarker assessments led by Dr. Daniel Johnson and his medical team. They offer science-backed nutrient therapies designed to enhance physical, emotional, and cognitive well-being, with IV drips and IM shots that deliver up to 100% bioavailable nutrients compared to 15-20% from oral intake. The practice uses a comprehensive micronutrient assessment measuring 52 nutritional components to customize each client's therapy plan, partnering with trusted compound pharmacies for high-quality ingredients.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Health-conscious professionals, athletes seeking performance optimization, individuals wanting proactive wellness assessments, people interested in nutrient replenishment therapies
    What sets them apart
    • Comprehensive blood test evaluating 52 nutritional components to identify deficiencies and personalize IV/IM therapy plans with a detailed nutritional report and food recommendations.
    • Led by Dr. Daniel Johnson and a trained medical team committed to proactive, science-backed wellness rather than reactive disease management.
    • Partners exclusively with industry-leading, award-winning compound pharmacies to ensure safety and efficacy of all IV drip, IM shot, and peptide ingredients.
    IV TherapyWellnessBiomarker TestingNutritionMedical-Grade
    Phone(714) 321-5387
    Orange County IV Lounge
    Updated 4/15/26Learn More →
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    Laguna Niguel, CA · 10 mi from Irvine
    Serves Laguna Niguel, Orange County, CA
    ★★★★★4.9(164 Google reviews)

    Hydration Room is a physician-founded IV and injection therapy clinic offering comprehensive wellness services including IV infusions, injectable therapies, NAD+ treatments, regenerative medicine, hormone support, and weight management solutions. Located in Laguna Niguel, the clinic features clinician-developed formulas and a team of licensed medical staff providing personalized treatments in a private, comfortable spa-like setting. With over 1.5 million therapies delivered across 50+ California locations, Hydration Room specializes in immune support, athletic recovery, beauty hydration, stress relief, and targeted wellness solutions tailored to individual health goals.

    Best for: Advanced longevity therapyAthletic performance optimizationLuxury wellness experience
    Ideal clients: Athletes and fitness enthusiasts, Wellness-focused professionals, Weight management seekers, Those addressing hormonal changes or deficiencies
    What sets them apart
    • All formulas are developed by clinicians and treatments are medically guided by licensed staff, ensuring clinical-level care in a wellness setting.
    • Individual treatment rooms provide a quiet, uninterrupted setting for those seeking privacy during their IV or injection therapy session.
    • Monthly membership plans offer significant savings with one IV per month, discounts on additional services, and exclusive member perks like free B12 shots and anniversary awards.
    IV TherapyWellness InfusionsNAD+ TreatmentWeight ManagementRegenerative Medicine
    Phone(949) 899-6924
    Hydration Room - Laguna Niguel
    Updated 4/15/26Learn More →
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    Irvine, CA
    Serves Irvine, CA and surrounding Orange County communities
    ★★★★★4.9(162 Google reviews)

    Hydration Room Irvine offers IV hydration therapy and wellness infusions administered by medical professionals in a relaxing spa setting. Located on Michelson Drive, they provide services including NAD+ therapy, athletic performance IVs, and customized hydration treatments designed to boost energy, recovery, and overall wellness. Their experienced medical staff delivers personalized care in a comfortable lounge environment.

    Best for: Advanced longevity therapyAthletic performance optimizationLuxury wellness experience
    Ideal clients: Athletes seeking recovery, wellness-focused professionals, individuals pursuing anti-aging treatments, busy executives needing energy optimization
    What sets them apart
    • All IV infusions are administered by licensed nurses and medical professionals, ensuring safe and proper treatment delivery.
    • Personalized IV therapy options including NAD+ therapy, athletic performance formulas, and hydration packages tailored to individual health goals.
    • Treatment provided in a private, comfortable lounge setting designed for relaxation and recovery.
    IV TherapyHydrationWellnessNAD+ TherapyMedical Spa
    Phone(949) 787-1511
    Hydration Room Irvine - Michelson Dr.
    Updated 4/15/26Learn More →
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    Villa Park, CA · 10 mi from Irvine
    Serves Villa Park, Orange County, California
    ★★★★★4.9(122 Google reviews)

    Hydration Room is a wellness center in Villa Park offering IV therapy services designed to boost energy, immunity, and athletic performance. Their medical staff administers customized IV infusions in a spa-like setting, with options ranging from hydration and nutrient therapies to specialized treatments like NAD+ therapy. They cater to athletes, busy professionals, and anyone seeking wellness optimization through science-backed intravenous treatments.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes seeking performance optimization, busy professionals needing energy and recovery, wellness enthusiasts interested in NAD+ therapy
    What sets them apart
    • Treatments are administered by qualified medical professionals (RN/MD), ensuring safe and effective IV therapy delivery in a clinical yet comfortable setting.
    • Offers comprehensive IV therapies including hydration, immunity boosters, athletic performance IVs, and NAD+ therapy for enhanced wellness and cellular health.
    • Private lounge setting combines the clinical expertise of IV therapy with the comfort and relaxation of a high-end wellness spa.
    IV TherapyWellness CenterNAD+ TherapyHydrationHealth
    Phone(714) 622-7671
    Hydration Room - Villa Park
    Updated 4/15/26Learn More →
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    Irvine, CA
    Serves Irvine, CA and surrounding Orange County communities
    ★★★★★5.0(42 Google reviews)

    Recharge Lab is an IV hydration and med spa clinic in Irvine offering IV therapy treatments, wellness services, and spa amenities. They specialize in hydration, nutrient infusions, and recovery therapies administered by medical staff in a relaxing spa setting. The clinic combines clinical IV services with a luxury med spa experience to support wellness, athletic performance, and recovery goals.

    Best for: Athletic performance optimizationLuxury wellness experience
    Ideal clients: Fitness enthusiasts and athletes, busy professionals seeking wellness, recovery-focused individuals, health-conscious residents seeking preventative wellness
    What sets them apart
    • IV therapies are administered by qualified medical professionals in a clinical setting, ensuring safety and efficacy for all treatments.
    • Combines clinical IV hydration with luxury spa amenities and relaxation services, creating a comprehensive wellness destination.
    • Offers targeted IV formulations for hydration, athletic performance, recovery, and wellness optimization.
    IV TherapyMed SpaWellnessHydrationRecovery
    Phone(949) 799-3282
    Recharge Lab | IV Hydration + Med Spa
    Updated 4/15/26Learn More →
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    Lake Forest, CA · 6 mi from Irvine
    Serves Lake Forest, Orange County, CA
    ★★★★★4.9(102 Google reviews)

    Hydration Room in Lake Forest offers IV therapy and hydration treatments designed to boost energy, immunity, athletic performance, and overall wellness. Their medical team administers customized IV infusions with vitamins, minerals, and electrolytes tailored to individual health goals. Whether you're recovering from a workout, fighting fatigue, or seeking preventive wellness support, they provide a professional spa-like setting for quick, effective treatments.

    Best for: Convenient at-home hydrationAthletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, busy professionals seeking energy and immune support, people recovering from illness or travel, wellness-focused individuals
    What sets them apart
    • Licensed medical professionals oversee all IV infusions, ensuring safety and proper dosing of vitamins and nutrients.
    • Treatments take place in a comfortable, relaxing private setting designed for wellness and recovery.
    • IV formulas are personalized based on your specific health goals, whether energy, immunity, athletic recovery, or hydration.
    IV TherapyWellnessHydrationHealth BoostingMedical Spa
    Phone(949) 736-1678
    Hydration Room - Lake Forest
    Updated 4/15/26Learn More →
    83
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    Anaheim, CA · 12 mi from Irvine
    Serves Anaheim Hills, Orange County, CA
    ★★★★★4.9(96 Google reviews)

    Hydration Room is a wellness center specializing in IV therapy services, including hydration, NAD+ therapy, athletic performance IVs, and wellness infusions. Located in Anaheim Hills, they provide professional IV treatments administered by medical staff in a spa-like setting designed for comfort and relaxation. The center offers both one-time treatments and membership plans for regular clients seeking performance optimization and wellness support.

    Best for: Advanced longevity therapyAthletic performance optimizationLuxury wellness experience
    Ideal clients: Athletes and fitness enthusiasts, Wellness-focused professionals, NAD+ therapy seekers, Busy professionals needing quick hydration and nutrient support
    What sets them apart
    • All IV treatments are administered by qualified nursing and medical staff, ensuring safety and proper protocol for every infusion.
    • Offers targeted therapies including NAD+ for cellular health, athletic performance IVs for recovery and endurance, and custom hydration solutions beyond standard wellness.
    • Private lounge setting with comfortable amenities creates a relaxing environment for IV treatments, not a clinical medical facility feel.
    IV TherapyWellnessNAD+ TherapyHydrationSpa Setting
    Phone(714) 695-5290
    Hydration Room - Anaheim Hills
    Updated 4/15/26Learn More →
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    Irvine, CA
    Serves Irvine, Orange County, CA
    ★★★★★4.9(81 Google reviews)

    LA Queen Med Spa is a full-service medical spa in Irvine offering advanced aesthetic and wellness treatments including IV therapy, injectables, laser services, facials, and body treatments. The spa combines medical-grade procedures with a luxury spa experience, staffed by licensed professionals dedicated to personalized skincare and rejuvenation. They specialize in customized treatments for anti-aging, skin enhancement, and overall wellness.

    Ideal clients: Anti-aging seekers, Wellness enthusiasts, Beauty-conscious professionals, Those seeking medical-grade skin treatments
    What sets them apart
    • Combines licensed medical professionals with advanced aesthetic procedures for safe, clinically-proven results.
    • Offers both beauty-focused treatments (injectables, lasers, facials) and health-focused services (IV therapy) under one roof.
    • Delivers medical treatments within a relaxing, high-end spa environment designed for comfort and rejuvenation.
    Med SpaIV TherapyInjectablesLaser ServicesWellness
    Phone(949) 981-1186
    LA Queen Med Spa
    Updated 4/15/26Learn More →
    82
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    Mission Viejo, CA · 7 mi from Irvine
    Serves Mission Viejo, CA and surrounding Orange County communities
    ★★★★★4.8(269 Google reviews)

    Restore Hyper Wellness in Mission Viejo offers IV therapy, NAD+ treatments, and wellness services designed to boost energy, recovery, and athletic performance. Their medical staff administers customized IV infusions in a spa-like setting, serving clients seeking hydration therapy, immune support, and anti-aging treatments. The center combines clinical expertise with a relaxing environment to help individuals optimize their health and wellness goals.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, Busy professionals seeking energy and recovery, Individuals interested in anti-aging wellness, People pursuing preventive health optimization
    What sets them apart
    • All IV infusions are administered by qualified medical professionals in a clinical setting, ensuring safety and proper care.
    • Treatments are tailored to individual wellness goals, from athletic recovery and immune support to energy enhancement and anti-aging.
    • Private lounge setting designed for comfort and relaxation during treatment sessions.
    IV TherapyNAD+ TherapyWellness CenterHydrationRecovery
    Phone(949) 994-8973
    Restore Hyper Wellness - Santa Margarita Pkwy
    Updated 4/15/26Learn More →
    82
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    Laguna Niguel, CA · 14 mi from Irvine
    Serves Laguna Niguel, CA and Orange County
    ★★★★★5.0(357 Google reviews)

    Restore Hyper Wellness is a premium wellness center in Laguna Niguel offering IV therapy (including NAD+, hydration, and performance drips), cryotherapy, red light therapy, infrared sauna, compression therapy, intramuscular shots, and advanced skin health services like HydraFacials and body contouring. Their science-backed approach combines cutting-edge modalities to support energy optimization, athletic recovery, anti-aging, and overall wellness through personalized treatment plans and flexible membership options.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, Anti-aging and longevity seekers, Busy professionals optimizing recovery and energy, Members seeking consistent wellness memberships
    What sets them apart
    • Offers integrated therapies across IV drips, cryotherapy, red light therapy, infrared sauna, compression, and skin health services—not just IV therapy alone. All services can be bundled through flexible membership plans with credits usable nationwide at other Restore locations.
    • Three tiered monthly membership options (Level Up, Elevate, Core) providing significant savings on core therapies and IV drips, plus 30% off specialty services and access to members-only events. Credits are flexible across multiple therapy types.
    • Specializes in NAD+ therapy available as both IV drips and intramuscular shots for cellular energy, anti-aging, and cognition support, alongside standard hydration and performance-focused IV formulations with medical staff administration.
    IV TherapyCryotherapyRed Light TherapyWellness CenterNAD+ Therapy
    Phone(949) 312-2626
    Restore Hyper Wellness - Golden Lantern
    Updated 4/15/26Learn More →
    81
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    Irvine, CA
    Serves Irvine, Orange County, California
    ★★★★★4.9(40 Google reviews)

    Integrative Medicine Orange County is a medical clinic in Irvine specializing in functional medicine, IV therapy, and holistic wellness approaches. Led by experienced medical professionals, the clinic combines conventional medical expertise with integrative therapies to address root causes of illness and optimize patient health. They offer comprehensive services including IV nutrient therapy, consultation for chronic conditions, and personalized wellness plans.

    Best for: Convenient at-home hydration
    Ideal clients: Patients seeking functional medicine approaches, individuals with chronic health conditions, wellness optimization, those interested in IV nutrient therapy
    What sets them apart
    • Uses advanced diagnostic testing and personalized protocols to identify and treat underlying health issues rather than just managing symptoms.
    • Provides medically-supervised intravenous nutrient and wellness therapies administered by qualified medical staff in a clinical setting.
    • Combines MDs and practitioners trained in both conventional and functional medicine disciplines for comprehensive whole-body treatment.
    Functional MedicineIV TherapyHolistic HealthMedical Clinic
    Phone(949) 398-7444
    Integrative Medicine Orange County
    Updated 4/15/26Learn More →
    81
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    Irvine, CA
    Serves Irvine, Orange County, CA
    ★★★★★4.8(87 Google reviews)

    Hydration Room in Irvine Center specializes in IV hydration therapy and wellness treatments designed to boost energy, immunity, and athletic performance. Their menu includes custom IV drips, NAD+ therapy, and wellness services administered by medical professionals in a spa-like setting. This location combines clinical expertise with a luxury wellness experience, making advanced hydration and nutrient therapies accessible for busy professionals and athletes.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, Busy professionals seeking energy and wellness optimization, Anti-aging and beauty-focused clients
    What sets them apart
    • All IV treatments are administered by licensed medical professionals in a clinical yet spa-like environment, ensuring safety and efficacy.
    • Services range from athletic performance and recovery IVs to immune support and beauty-focused hydration treatments, tailored to individual wellness goals.
    • Specialized anti-aging and cellular rejuvenation treatments in addition to standard hydration therapies.
    IV TherapyNAD+ TherapyWellnessHydrationMedical Spa
    Phone(949) 620-4106
    Hydration Room - Irvine Center
    Updated 4/15/26Learn More →
    81
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    Newport Beach, CA · 8 mi from Irvine
    Serves Newport Beach, Orange County, CA
    ★★★★★4.8(70 Google reviews)

    Hydration Room Newport Beach is a wellness center specializing in IV therapy and hydration services. Located in Newport Center, this spa-like facility offers customized IV drips designed to boost energy, immune function, athletic performance, and overall wellness. With a focus on premium hydration solutions and personalized health support, they serve clients seeking quick, effective wellness optimization in a relaxing environment.

    Best for: Athletic performance optimization
    Ideal clients: Busy professionals, athletes and fitness enthusiasts, individuals seeking immune support, wellness-conscious residents in Orange County
    What sets them apart
    • Hydration Room offers tailored IV therapy blends designed for specific wellness goals, including energy enhancement, immune support, and athletic recovery.
    • Located in upscale Newport Center, the facility provides a premium, relaxing setting for IV therapy sessions with professional medical staff.
    • IV therapy delivers fast-acting hydration and nutrient absorption without the digestive breakdown, ideal for busy professionals and active individuals.
    IV TherapyHydrationWellness CenterNewport Beach
    Phone(949) 818-2518
    Hydration Room Newport Beach - Newport Center Dr
    Updated 4/15/26Learn More →
    81
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    Irvine, CA
    Serves Irvine, CA and Orange County
    ★★★★★4.7(1683 Google reviews)

    Premium Health is a wellness clinic in Irvine specializing in weight loss programs, IV therapy, and medical wellness services. Founded to help clients achieve sustainable health goals, they combine personalized treatment plans with advanced medical interventions including NAD+ therapy and athletic performance optimization. Their experienced medical staff delivers results-driven care in a professional, supportive environment.

    Best for: Advanced longevity therapyAthletic performance optimizationLuxury wellness experience
    Ideal clients: Weight loss seekers, Athletes and fitness enthusiasts, Wellness optimization, Anti-aging and longevity focused individuals
    What sets them apart
    • Evidence-based weight loss protocols combining medical supervision, personalized nutrition guidance, and cutting-edge treatments tailored to individual metabolic needs.
    • Specializes in NAD+ therapy and athletic performance IVs administered by qualified medical staff in a professional wellness setting.
    • Medical professionals on-site providing evidence-based care and ensuring safe, effective treatment protocols for all wellness services.
    Weight LossIV TherapyMedical WellnessNAD+ TherapyHealth Optimization
    Phone(888) 700-0750
    Premium Health
    Updated 4/15/26Learn More →
    80
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    Santa Ana, CA · 5 mi from Irvine
    Serves Santa Ana, Orange County, CA
    ★★★★★5.0(19 Google reviews)

    Evolve Longevity Center is a specialized medical clinic in Santa Ana focused on hormone replacement therapy (HRT), hormone optimization, and menopause management. Led by experienced physicians, they provide personalized treatment plans addressing hormonal imbalances, menopausal symptoms, and age-related wellness concerns for both men and women. The clinic combines evidence-based medicine with a patient-centered approach to help clients restore vitality and quality of life.

    Ideal clients: Women navigating menopause, Men seeking hormone optimization, Adults interested in longevity medicine
    What sets them apart
    • Dedicated clinic focused specifically on hormone replacement therapy and hormonal health, not a general practice offering it as one service among many.
    • Specializes in managing menopause symptoms and hormone imbalances for women and men seeking hormone optimization and longevity-focused treatment.
    • Physicians create individualized hormone therapy protocols based on patient labs and goals rather than one-size-fits-all approaches.
    Hormone TherapyMenopause TreatmentHRTHormone OptimizationLongevity Medicine
    Phone(949) 486-6006
    Evolve Longevity Center - HRT, Hormone Therapy & Menopause Clinic
    Updated 4/15/26Learn More →
    80
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    Irvine, CA
    Serves Irvine, Orange County, CA
    ★★★★★4.9(27 Google reviews)

    Wei Aesthetic Institute is a medical spa and skin care clinic in Irvine led by experienced aesthetic physicians. They offer a comprehensive range of services including injectables (Botox, fillers), laser treatments, chemical peels, microneedling, and other advanced skin rejuvenation procedures. The institute combines medical expertise with spa-quality care to deliver personalized aesthetic treatments for clients seeking professional, results-driven skin enhancement.

    Ideal clients: Professionals seeking non-invasive skin rejuvenation, clients wanting physician-supervised aesthetic treatments, those interested in preventative anti-aging care
    What sets them apart
    • Treatments are overseen by experienced aesthetic physicians, ensuring medical-grade safety and expertise.
    • Offers a full spectrum of treatments from injectables and fillers to advanced laser and skin rejuvenation procedures under one roof.
    • Combines clinical precision with spa-quality comfort and environment for a premium aesthetic experience.
    Medical SpaAesthetic MedicineLaser TreatmentsInjectablesSkin Care
    Phone(949) 748-3880
    Wei Aesthetic Institute
    Updated 4/15/26Learn More →
    80
    Lantern
    Score
    Irvine, CA
    Serves Irvine, Orange County, CA
    ★★★★★4.8(41 Google reviews)

    One Beauty Aesthetics is a premier skincare and aesthetic treatment clinic in Irvine specializing in advanced facial treatments, body treatments, and injectable services. The clinic offers a comprehensive range of services including HydraFacial, microneedling, chemical peels, laser treatments, Botox, dermal fillers, and body contouring procedures. With a focus on personalized treatment plans and cutting-edge technology, One Beauty Aesthetics serves clients seeking professional aesthetic enhancements and skin rejuvenation.

    Ideal clients: Anti-aging clients, skin rejuvenation seekers, individuals wanting non-invasive aesthetic treatments, busy professionals seeking quick results
    What sets them apart
    • Utilizes state-of-the-art equipment including HydraFacial systems, laser technology, and professional-grade microneedling devices for optimal results.
    • Offers both non-invasive skincare treatments and injectable services, providing clients with a full range of aesthetic solutions under one roof.
    • Develops customized treatment plans tailored to individual skin types and aesthetic goals rather than one-size-fits-all services.
    SkincareAesthetic TreatmentsInjectablesHydraFacialAnti-Aging
    Phone(626) 532-0515
    One Beauty Aesthetics - Irvine
    Updated 4/15/26Learn More →
    80
    Lantern
    Score
    Irvine, CA
    Serves Irvine, CA and surrounding Orange County areas
    ★★★★★4.8(39 Google reviews)

    Hydration Room Irvine offers IV therapy treatments designed to boost energy, immunity, athletic performance, and overall wellness. Located in Northpark Plaza, this wellness center provides professional IV infusions administered by medical staff in a comfortable spa-like setting. They offer customized hydration and nutrient solutions for various health goals, from recovery and hangover relief to beauty and athletic enhancement.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes and active individuals, Busy professionals seeking energy boosts, Wellness-focused individuals, People recovering from illness or hangovers
    What sets them apart
    • IV treatments are administered by qualified medical professionals in a clean, professional environment.
    • Tailored IV infusions designed for specific health goals including energy, immunity, athletic performance, and recovery.
    • Comfortable, relaxing environment that makes wellness treatments feel like a self-care experience.
    IV TherapyWellnessHydrationHealth ServicesIrvine
    Phone(949) 368-0407
    Hydration Room Irvine - Northpark Plaza
    Updated 4/15/26Learn More →
    79
    Lantern
    Score
    Costa Mesa, CA · 9 mi from Irvine
    Serves Costa Mesa, Orange County, CA and surrounding areas
    ★★★★★4.9(102 Google reviews)

    Beyond Wellness specializes in advanced wellness therapies including hyperbaric oxygen chamber treatments, NAD+ therapy, and peptide protocols designed to enhance energy, recovery, and cellular health. Located in Costa Mesa, they combine cutting-edge medical technologies with personalized treatment plans to help clients optimize performance, slow aging, and support overall wellness goals.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, Biohackers seeking performance optimization, Professionals targeting anti-aging and energy, Recovery-focused individuals
    What sets them apart
    • Offers integrated hyperbaric oxygen therapy, NAD+ infusions, and peptide protocols in one facility, allowing clients to combine treatments for synergistic results.
    • Specializes in therapies targeting cellular regeneration and athletic/cognitive performance rather than general wellness, attracting biohackers and serious fitness enthusiasts.
    NAD+ TherapyHyperbaric OxygenPeptide TherapyCellular HealthPerformance Optimization
    Phone(949) 776-1393
    Beyond Wellness | Hyperbaric Chamber, NAD Therapy and Peptides
    Updated 4/15/26Learn More →
    79
    Lantern
    Score
    Newport Beach, CA · 7 mi from Irvine
    Serves Newport Beach and Orange County, CA
    ★★★★★5.0(15 Google reviews)

    Hydrate Now is a wellness center in Newport Beach offering IV therapy, hydration treatments, and spa services. They provide a range of wellness services including IV infusions designed to boost energy, immunity, athletic performance, and overall health, delivered in a comfortable spa-like setting. The center combines medical-grade treatments with relaxation amenities to support preventive wellness and recovery.

    Best for: Athletic performance optimization
    Ideal clients: Athletes and active individuals, busy professionals seeking wellness optimization, health-conscious individuals, recovery and hydration support
    What sets them apart
    • IV therapy delivered in a comfortable, relaxing environment with wellness amenities rather than a clinical setting.
    • Customized IV infusions for hydration, energy, immunity support, athletic performance, and overall wellness recovery.
    • Located in Newport Center with easy access and flexible scheduling for busy professionals and wellness seekers.
    IV TherapyWellnessHydrationSpaNewport Beach
    Phone(949) 214-4297
    Hydrate Now
    Updated 4/15/26Learn More →
    78
    Lantern
    Score
    Tustin, CA · 3 mi from Irvine
    Serves Tustin, Orange County, CA
    ★★★★★4.8(242 Google reviews)

    Restore Hyper Wellness is a wellness center in Tustin offering IV therapy, NAD+ treatments, and other advanced wellness services designed to boost energy, recovery, and athletic performance. Their medical staff administers customized IV therapies in a spa-like setting, catering to clients seeking preventative wellness, athletic enhancement, and health optimization.

    Best for: Advanced longevity therapyAthletic performance optimization
    Ideal clients: Athletes and fitness enthusiasts, Professionals seeking energy optimization, Individuals interested in preventative wellness
    What sets them apart
    • IV therapies are administered by qualified medical professionals, ensuring safety and proper dosing for each client's wellness goals.
    • Treatments are tailored to individual needs, whether for athletic recovery, energy boost, immune support, or anti-aging wellness.
    • Private lounge environment combines clinical efficacy with comfort, making wellness treatments feel like a luxury experience.
    IV TherapyWellness CenterNAD+ TherapyRecovery
    Phone(714) 912-9731
    Restore Hyper Wellness - El Camino Real
    Updated 4/15/26Learn More →
    78
    Lantern
    Score
    Costa Mesa, CA · 9 mi from Irvine
    Serves Costa Mesa, CA and surrounding Orange County areas
    ★★★★★4.9(44 Google reviews)

    New Hope Vitality is a wellness center in Costa Mesa specializing in regenerative medicine and performance optimization through stem cell therapy, IV therapy, and peptide treatments. The clinic offers personalized protocols designed to support cellular health, recovery, and longevity for clients seeking advanced wellness solutions beyond conventional medicine.

    Ideal clients: Athletes and active individuals, Longevity-focused wellness seekers, Recovery and regeneration enthusiasts, Performance optimization clients
    What sets them apart
    • Offers advanced stem cell treatments alongside IV and peptide protocols, providing a comprehensive regenerative medicine approach not commonly found in standard wellness clinics.
    • Integrates peptide therapies into personalized treatment plans, addressing specific wellness goals from recovery to performance optimization.
    • Combines multiple modalities (stem cells, IV therapy, peptides) into customized wellness protocols tailored to individual health objectives.
    Stem Cell TherapyIV TherapyPeptidesRegenerative MedicineWellness
    Phone(949) 773-2774
    New Hope Vitality | Stem Cells, IV Therapy, Peptides
    Updated 4/15/26Learn More →
    69
    Lantern
    Score
    San Juan Capistrano, CA · 14 mi from Irvine
    Serves San Juan Capistrano, Orange County, CA
    ★★★★★5.0(5 Google reviews)

    OC IV Wellness is a wellness spa in San Juan Capistrano offering intravenous therapy services designed to boost health, energy, and overall wellness. They provide IV infusions in a professional spa setting, catering to clients seeking nutrient optimization and recovery support.

    Ideal clients: Health-conscious individuals, Athletes seeking recovery optimization, Busy professionals wanting wellness boosts, People interested in IV nutrient therapy
    What sets them apart
    • OC IV Wellness combines medical IV therapy with a relaxing spa environment, making wellness treatments more comfortable and accessible.
    • Located in central San Juan Capistrano, making IV wellness services easily accessible to South Orange County residents and visitors.
    IV TherapyWellness SpaIV InfusionsHealth OptimizationSan Juan Capistrano
    Phone(530) 788-3383
    OC IV Wellness
    Updated 4/15/26Learn More →

    Frequently Asked Questions

    Who is the top-ranked IV therapy provider in Irvine?

    Prime IV Hydration & Wellness in Brea is the top-ranked provider with a Lantern Score of 85.12/100 and 5★ rating from 164 reviews. They specialize in IV vitamin infusions and wellness treatments for fitness enthusiasts, frequent travelers, anti-aging seekers, and busy professionals needing quick wellness boosts.

    Which IV therapy clinics in Irvine are best for athletes?

    The DRIPBaR Huntington Beach (Lantern Score: 84.77/100) and Hydration Room Irvine - Michelson Dr. (Lantern Score: 83.42/100) both specialize in athletic performance IVs and recovery treatments. The DRIPBaR offers dedicated athletic performance infusions and NAD+ therapy, while Hydration Room Irvine provides customized IV infusions in a spa setting specifically designed for athlete recovery.

    What options exist for anti-aging and wellness optimization in Irvine?

    Ohmi Anti-Aging Center (Lantern Score: 84.66/100) is an award-winning regenerative aesthetics clinic in Irvine with 5★ rating from 101 reviews, led by Dr. Maxwell Jen, MD. For preventative wellness, Biolite Wellness (Lantern Score: 83.47/100) offers a holistic approach combining medical weight loss and aesthetic treatments, founded by a Harvard and Stanford-trained physician-scientist.

    Which IV therapy provider offers mobile services to your home or office?

    IV ME UP (Lantern Score: 84.57/100) is a mobile IV therapy service based in Newport Beach that delivers wellness treatments directly to clients' homes, offices, and hotels throughout Orange County and parts of Los Angeles County. It's ideal for busy professionals, post-workout athletes, and event preparation.

    Who is best for weight management and medical weight loss programs?

    Premium Health (Lantern Score: 80.59/100) in Irvine specializes in weight loss programs combined with IV therapy and medical wellness services, with 4.7★ rating from 1,683 reviews. Alternatively, Ohmi Anti-Aging Center (Lantern Score: 84.66/100) offers medically supervised weight management as part of their comprehensive wellness services.

    Which IV wellness clinics offer NAD+ therapy in the Irvine area?

    Multiple top-ranked providers offer NAD+ therapy: The DRIPBaR Huntington Beach (84.77/100), WeVitalize in Huntington Beach (84.24/100), and three Hydration Room locations including Irvine - Michelson Dr. (83.42/100) and Irvine Center (81.16/100). All are rated 4.8-5★ and provide physician-administered NAD+ treatments for energy and wellness optimization.

    This directory of iv therapy & wellness clinics local businesses serving Irvine, CA is maintained by Lantern. Rankings are determined by the Lantern Score — not advertising or payment for placement. Learn how it works. Last updated April 15, 2026. To claim or update a listing, contact us.